Cancer and Cardiac Screenings

Discover our lifesaving comprehensive genetic testing services powered by world leading RANDOX at Letterkenny Medics. This is the first type of testing service available in the county and Letterkenny Medics is proud to be the first to offer it.

Understand your heart health with our Hereditary Cardiac Testing. Discover genetic insights into 17 inherited cardiac conditions, covering 174 different genes. Lifestyle factors also play a role, but our expert team is here to guide you through tailored options for risk reduction.

Empower yourself with knowledge through our Genetic Cancer Screening. With 94 genes analysed, including those linked to breast, ovarian, prostate, colorectal, and thyroid cancers, take proactive measures based on your genetic risk. Your well-being is our priority. 

If a genetic variant is detected, we refer you to genetic experts who will develop personalised strategies like lifestyle changes, regular screening, medication, and in some cases, risk-reducing surgery.

Your family's health matters too – we offer testing for close relatives.

Contact our clinic for pricing and information.

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GENETIC TESTS:

A-FULL HEREDITARY CANCER GENE :Expert-defined content targeting 113 genes associated with genetic cancer risk predisposition, including, breast, ovarian, colon, gastric and other inherited cancer syndromes. Gene List AIP ALK APC ATM BAP1 BLM BMPR1A BRCA1 BRCA2 BRIP1 BUB1B CDC73 CDH1 CDK4 CDKN1C CDKN2A CEBPA CEP57 CHEK2 CYLD DDB2 DICER1 DIS3L2 EGFR EPCAM ERCC2 ERCC3 ERCC4 ERCC5 EXT1 EXT2 EZH2 FANCA FANCB FANCC FANCD2 FANCE FANCF FANCG FANCI FANCL FANCM FH FLCN GATA2 GPC3 HNF1A HRAS KIT MAX MEN1 MET MLH1 MSH2 MSH6 MUTYH NBN NF1 NF2 NSD1 PALB2 PHOX2B PMS1 PMS2 PRF1 PRKAR1A PTCH1 PTEN RAD51C RAD51D RB1 RECQL4 RET RHBDF2 RUNX1 SBDS SDHAF2 SDHB SDHC SDHD SLX4 SMAD4 SMARCB1 STK11 SUFU TMEM127 TP53 TSC1 TSC2 VHL WRN WT1 XPA XPC

B- HEREDITARY CANCER 29 GENE: Expert-defined content targeting 29 genes associated with more common inherited cancer syndromes.-  Gene List :APC ATM BMPR1A BRCA1 BRCA2 CDKN2A CHEK2 FLCN MEN1 MET MLH1 MSH2 MSH6 MUTYH NBN PALB2 PMS1 PMS2 PTEN RAD51C RAD51D RB1 RET SMAD4 STK11 TP53 TSC1 TSC2 VHL

C- HEREDITARY CANCER- BREAST AND OVARIAN RISK: Our hereditary breast and ovarian cancer genetic risk test covers 8 different genes including BRCA1 and BRCA2 associated with both hereditary breast and ovarian cancer. Gene List ATM BRCA1 BRCA2 CDH1 CHEK2 PALB2 PTEN TP53

D- HEREDITARY CANCER PROSTATE CANCER, Gene List ATM BRCA1 BRCA2 CDH1 CHEK2 PALB2 PTEN TP53

E-FULL HEREDITARY CARDIAC RISK: A comprehensive, cost-effective solution for identifying causal variants implicated in inherited cardiac conditions (ICCs)- Gene List: ABCC9 ABCG5 ABCG8 ACTA1 ACTA2 ACTC1 ACTN2 AKAP9 ALMS1 ANK2 ANKRD1 APOA4 APOA5 APOB APOC2 APOE BAG3 BRAF CACNA1C CACNA2D1 CACNB2 CALM1 CALR3 CASQ2 CAV3 CB2 CBL CETP COL3A1 COL5A1 COL5A2 COX15 CREB3L3 CRELD1 CRYAB CSRP3 CTF1 DES DMD DNAJC19 DOLK DPP6 DSC2 DSG2 DSP DTNA EFEMP2 ELN EMD EYA4 FBN1 FBN2 FHL1 FHL2 FKRP FKTN FXN GAA GATAD1 GCKR GJAS GLA GPD1L GPIHBP1 HADHA HCN4 HFE HRAS HSPB8 ILK JAG1 JPH2 JUP KCNA5 KCND3 KCNE1 KCNE2 KCNE3 KCNH2 KCNJ2 KCNJ5 KCNJ8 KCNQ1 KLF10 KRAS LAMA2 LAMA4 LAMP2 LDB3 LDLR LDLRAP1 LMF1 LMNA LPL LTBP2 MAP2K1 MAP2K2 MIB1 MURC MYBPC3 MYH11 MYH6 MYH7 MYL2 MYL3 MYLK MYLK2 MYO6 MYOZ2 MYPN NEXN NKX2-5 NODAL NOTCH1 NPPA NRAS PCSK9 PDLIM3 PKP2 PLN PRDM16 PRKAG2 PRKAR1A PTPN11 RAF1 RANGRF RBM20 RYR1 RYR2 SALL4 SCN1B SCN2B SCN3B SCN4B SCN5A SCO2 SDHA SEPN1 SGCB SGCD SGCG SHOC2 SLC25A4 SLC2A10 SMAD3 SMAD4 SNTA1 SOS1 SREBF2 TAZ TBX20 TBX3 TBX5 TCAP TGFB2 TGFB3 TGFBR1 TGFBR2 TMEM43 TMPO TNNC1 TNNI3 TNNT2 TPM1 TRDN TRIM63 TRPM4 TTN TTR TXNRD2 VCL ZBTB17 ZHX3 ZIC3

F-GENETIC CELIAC DISEASE: Detection of HLA-DQB1*02, DQB1*03:02, DQA1*05 and DQA1*03 alleles by RT-PCR, from extracted genomic DNA in whole blood, and the consequent determination of DQ2 and DQ8 antigens associated to coeliac disease,Gene List :HLA-DQ2 HLA-DQ8

G-GENETIC LACTOSE INTOLERANCE For detecting the C13910T and G22018A polymorphisms of the MCM6 gene by RT-PCR  Gene List C13910T G22018A

H-GENETIC HEMOCHROMATOSIS Detection of polymorphisms p.His63Asp, p.Ser65Cys and p.Cys282Tyr in the HFE gene associated with Hemochromatosis. Confirmatory diagnostic genetic testing to diagnose or rule out HH should be carried out for symptomatic individuals with biochemical evidence of iron overload. Gene List HFE C282Y HFE H63D HFE S65C

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